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| Τυχαιοποιημένο Προσαρμοστικό Πείραμα Συμπλεγμάτων× | Τυχαιοποιημένη Ελεγχόμενη Δοκιμή με Ομάδες (Blocked Randomized Controlled Trial)× | |
|---|---|---|
| Πεδίο | Πειραματικός Σχεδιασμός | Πειραματικός Σχεδιασμός |
| Οικογένεια | Process / pipeline | Process / pipeline |
| Έτος προέλευσης≠ | 2000s–2010s | 1920s (Fisher's blocking principle); applied to RCTs from the 1940s onward |
| Δημιουργός≠ | Synthesised from cluster randomization methodology (Donner, 1978; Donner & Klar, 2000) and adaptive design frameworks (Bauer & Kohne, 1994; Pallmann et al., 2018) | R. A. Fisher (blocking principle); systematic RCT application by Bradford Hill and later Pocock, Friedman et al. |
| Τύπος | Experimental design | Experimental design |
| Θεμελιώδης πηγή≠ | Hayes, R. J., & Moulton, L. H. (2017). Cluster Randomised Trials (2nd ed.). CRC Press / Chapman & Hall. ISBN: 978-1498728225 | Friedman, L. M., Furberg, C. D., DeMets, D. L., Reboussin, D. M., & Granger, C. B. (2010). Fundamentals of Clinical Trials (4th ed.). Springer. ISBN: 978-1441915856 |
| Εναλλακτικές ονομασίες | adaptive cluster RCT, adaptive group-randomized trial, cluster adaptive design, adaptive cluster trial | blocked RCT, block-randomized trial, stratified block randomization trial, permuted block randomization |
| Συναφείς | 5 | 5 |
| Σύνοψη≠ | A cluster randomized adaptive experiment combines two methodological principles: (1) intact groups such as schools, clinics, or villages are randomly assigned to treatment conditions rather than individuals, and (2) pre-specified rules allow the design to be modified during the trial based on accumulating cluster-level data. Adaptations may include dropping underperforming arms, reallocating clusters, or adjusting sample size, while maintaining statistical validity and controlling Type I error. | A blocked randomized controlled trial (blocked RCT) uses permuted-block randomization to ensure that treatment groups remain balanced in size — and optionally in key characteristics — throughout recruitment. Within each block of fixed or randomly varied size, all treatment allocations are present in equal numbers, so imbalance cannot accumulate even if the trial is stopped early. This makes blocked RCTs the standard randomization approach in clinical and behavioral intervention research. |
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