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Method evidence record

NOESY

Nuclear Overhauser Enhancement Spectroscopy (NOESY) is a 2D NMR technique that detects through-space dipolar coupling between protons, rather than through-bond scalar coupling. Introduced by Macura and Ernst in 1981, NOESY reveals which protons are spatially close in the three-dimensional structure, independent of bonding connectivity. This makes NOESY invaluable for determining molecular conformation, assigning stereochemistry, and elucidating protein folds.

Evidence statusSources recorded, not reviewedBibliographic sources are present. Claim-level evidence review has not been performed.

Source record

Recorded

Citations copied verbatim from the method’s source record. No claim-level verification is inferred from them.

Nuclear Overhauser Enhancement Spectroscopy

Taxonomic method recordprocess-pipelinespectroscopy

  1. Aue, W. P., Bartholdi, E., & Ernst, R. R. (1976). Two-dimensional spectroscopy. Application to nuclear magnetic resonance. The Journal of Chemical Physics, 64(5), 2229-2246. · DOI 10.1063/1.432450

  2. Macura, S., & Ernst, R. R. (1981). Elucidation of cross relaxation in liquids by two-dimensional NMR spectroscopy. Molecular Physics, 41(1), 95-117. · DOI 10.1080/00268978000102601

  3. Wüthrich, K. (1986). NMR of Proteins and Nucleic Acids. John Wiley & Sons. · URL

Open full method3 recorded citations, copied from the method source record.

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Related methods

Suggested3

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