Method evidence record

Dissolution f1/f2 Similarity

The f1 and f2 factors are dimensionless statistical measures developed by Moore and Flanner to quantify the similarity between two dissolution profiles. Adopted by regulatory agencies (FDA, EMA) as the gold standard for comparing dissolution curves, these factors enable rapid assessment of whether formulation changes significantly impact drug release.

Evidence statusSources recorded, not reviewedBibliographic sources are present. Claim-level evidence review has not been performed.