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Method evidence record

Circular Dichroism

Circular Dichroism (CD) spectroscopy measures the differential absorption of left- and right-circularly polarized light by optically active molecules, particularly proteins and nucleic acids. Introduced by Greenfield and Fasman in 1969, CD is a rapid, non-destructive technique for characterizing secondary structure (alpha-helix, beta-sheet), monitoring protein folding transitions, and assessing conformational changes in response to pH, temperature, or ligand binding.

Evidence statusSources recorded, not reviewedBibliographic sources are present. Claim-level evidence review has not been performed.

Source record

Recorded

Citations copied verbatim from the method’s source record. No claim-level verification is inferred from them.

Circular Dichroism Spectroscopy

Taxonomic method recordprocess-pipelinespectroscopy

  1. Greenfield, N. J., & Fasman, G. D. (1969). Computed circular dichroism spectra for protein secondary structures. Biochemistry, 8(10), 4108-4116. · DOI 10.1021/bi00838a031

  2. Yang, J. T., Wu, C. S., & Martinez, H. M. (1986). Calculation of protein conformation from circular dichroism. Methods in Enzymology, 130, 208-269. · DOI 10.1016/0076-6879(86)30013-2

Open full method2 recorded citations, copied from the method source record.

Curated claims

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No curated claims yet

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Related methods

Suggested3

Generated from the method graph and shown as machine-suggested relations. No evidence claim is inferred.