Pragmatic Factorial Experiment
A pragmatic factorial experiment combines two powerful methodological frameworks: the factorial experimental design — which tests multiple intervention components simultaneously — and the pragmatic trial orientation, which prioritizes real-world applicability, broad eligibility criteria, and flexible delivery conditions. The result is a design that efficiently evaluates which components of a complex intervention work, and whether they interact, while maintaining ecological validity for health, behavioral, and educational research.
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- Loudon, K., Treweek, S., Sullivan, F., Donnan, P., Thorpe, K. E., & Zwarenstein, M. (2015). The PRECIS-2 tool: designing trials that are fit for purpose. BMJ, 350, h2147. · DOI 10.1136/bmj.h2147
- Collins, L. M., Murphy, S. A., & Strecher, V. (2007). The Multiphase Optimization Strategy (MOST) and the Sequential Multiple Assignment Randomized Trial (SMART): New Methods for More Potent eHealth Interventions. American Journal of Preventive Medicine, 32(5 Suppl), S112–S118. · DOI 10.1016/j.amepre.2007.01.022
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